k562 cell — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13224	Tubulin inhibitor 6	iHAP1	Microtubule Associated
	Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.		Microtubule Associated
T2394	Pixantrone dimaleate	BBR-2778,Pixantrone Maleate,BBR 2778 dimaleate	Topoisomerase
	Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.		Topoisomerase
T1511	Daunorubicin hydrochloride	Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic , Autophagy
	Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
T13226	Tubulin inhibitor 8		Microtubule Associated
	Tubulin inhibitor 8 is an inhibitor of tubulin and various cancer cell lines and inhibits tubulin polymerisation and K562 cell growth with an IC50 of 0.73 μM and 14 nM respectively.		Microtubule Associated
T12926	SJB3-019A		Others , DUB
	SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times more than SJB2-043, with IC50 of 0.0781 μM. SJB3-019A inhibits...		Others , DUB
T1937	Spautin-1	Spautin 1	Apoptosis , DUB , Autophagy
	Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.		Apoptosis , DUB , Autophagy
TN2755	2-Desoxy-4-epi-pulchellin		Anti-infection
	2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows sig...		Anti-infection
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T4S1943	Kirenol	Kirel	Wnt/beta-catenin
	1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid...		Wnt/beta-catenin
T6S1315	Oroxylin A	6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...		Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
T3398	Icaritin	Anhydroicaritin,Cycloicaritin	Apoptosis , JAK , STAT , Autophagy
	Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica...		Apoptosis , JAK , STAT , Autophagy
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T1817	GNF-2	GNF2	SARS-CoV , Bcr-Abl
	GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.		SARS-CoV , Bcr-Abl
TN5358	Eupahualin C
	Eupahualin C shows significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).
T81232	S-30-Hydroxygambogic acid
	"S-30-Hydroxygambogic acid, a polyprenylated xanthone epimer isolated from the gamboges of Garcinia hanburyi, exhibits cytotoxicity against Human Leukemia K562 cell lines with IC50 values of 4.49 μM for K562/R and 3.61 μ...
T13225	Tubulin inhibitor 7		Microtubule Associated
	Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (IC50: 11 nM)).		Microtubule Associated
TN2192	Scutebarbatine B		Others
	Scutebarbatine B shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines and HL60 cell lines.		Others
TN3760	Danshenol A		Reductase
	Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and B...		Reductase
T81318	R-30-Hydroxygambogic acid
	R-30-Hydroxygambogic acid, a polyprenylated xanthone epimer isolated from the gamboge of Garcinia hanburyi, exhibits cytotoxicity against human leukemia K562 cell lines, with IC50 values of 2.89 μM for the resistant stra...
TN4976	Scutebata E		Others
	Scutebata E shows weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines.		Others